In Vivo Self-Assembly Nanotechnology for Biomedical Applications by Hao Wang & Li-Li Li

Author:Hao Wang & Li-Li Li
Language: eng
Format: epub
Publisher: Springer Singapore, Singapore

(3)The adequate penetration into the tumor can be got because of the size of precursor. Compared to the shallow penetration of nanoparticle into tumor, which is limited by interstitial pressure, it is much easier for small molecules (precursor) to penetrate deep inside of tumor and even tumor cells by means of passive diffusion or active transportation. Besides, there are more choices to design the appropriate precursor to get better ability of penetration into tumor.

(4)The delivery efficiency is quite sufficient. The EISA depends on the over-expression of certain enzyme rather than cell surface receptor or vascular leakage, which indicate that it can increase the opportunity of entering cells. Because that overexpressed enzyme is the intrinsic component in tumor cells, ideally, the enzyme-instructed self-assembly will proceed only in tumor cells and get small molecules accumulated. When the concentration is over CAC, the intracellular concentration of small molecules would reach millimolar level and the self-assembly occurs, which can satisfy the need of preloaded or post-delivered therapeutic agents.

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